The Foundation aims to support medical and scientific research to accelerate the discovery of new ways to combat the above-mentioned diseases. To this end, it awards an annual prize, the « ROGER DE SPOELBERCH » prize, to a research project carried out in European university hospitals.

A Scientific Committee composed of eminent European doctors and professors specialized in neurosurgery, medical imaging, psychiatry and other fields, has been entrusted with the task of selecting researchers who have made a significant contribution to medical and scientific research. Each year, it awards substantial financial support to one of them, enabling them to pursue their work, which is particularly useful in the fight against neurodegenerative diseases.

The Foundation identifies hospitals, public or private clinics or associations that care for people suffering from neurodegenerative diseases, and those to which it could provide  one-off financial support, by financing new infrastructures or supporting new projects, so that these institutions can better welcome and care for patients, and thus improve their quality of life and that of their caregivers, with the aim of providing them with an alternative source of financing.

The Foundation is apolitical and non-denominational, and its actions are not geographically limited in any way, although it does wish to concentrate its efforts on European territory in the first instance.